I think speed is a problem--unless Sale was in hold-back mode. But he also threw 100 pitches in 5 innings, which is not too promising.
However, in the Yanks series, it may not matter too much, since Severino will pitch on Tuesday, and would only get one start vs. Sox (if my math is right). So you have Happ and some question marks to rely on in the four other games. Despite my little concerns I like the Sox odds.
If there is a Sale problem, I think it would present much more in the subsequent longer series.