Well, a lot of fans felt that not replacing David Ortiz - or effectively replacing him with Mitch Moreland - was a mistake. Especially with Edwin Encarnacion drawing limited interest from the league and overtly stating he wanted to come to Boston to replace Ortiz, as he felt that would be an honor to follow his fellow countryman. That decision did have drastic ramifications, as the Sox came in last in the AL in home runs by a very, very wide margin and Encarnacion finished tied for 8th in the AL with 38 HRs. (Moreland did hit 22, but was a significantly lesser player offensively than Encarnacion.)
Of course, it is entirely possible Dombrowski was not exactly enamored with Encarnacion, as he would later turn down a Bradley-Encarnacion trade offer. (That may have also been turned down for other reasons, as well.)