Erik Bedard is 5-4 with a 4.25 ERA in 12 career starts vs. the Sox. I've always been a fan of Bedard, he has a 3.88 career ERA in a lot of innings in the AL East, but he was always hurt.
In addition, he started this year as a reliever so he hasn't thrown many innings in his start, so we may be able to feast on Houston's bullpen even if we don't light Bedard up.