There already are key injuries IMO.
Mayer could be out for a while and there isn't a good solution at 2b. They will end up putting Rafaela at 2b most likely, which helps the offense, but hurts the defense (Masa will have to put on football pads to play LF with Duran out there apparently).
Bregman is now physically limited. We don't know if his leg will get better over time, or if it just needs offseason rest.
Dobbins is out.
Tanner is out.
Significant 60 day IL: Casas, Crawford, Winckowski, Slaten (all expected to be contributors prior to the season)