It's just like the old NL Central/AL West. I don't think it'll affect who makes the playoffs based on the settings (division leaders makes playoffs, and then top records), unless all 6 teams in that one division have a better record than all 4 teams in the other division.
Also I don't know if it could still be changed, but since there's only 10 teams this season maybe there should only be 4 playoff spots rather than 6.