Yup, each knuckleballer is a distinct animal. They talk about it in the Knuckleball! doc. It's hard for guys to coach one another when things go awry because each guy truly has a unique pitch.
Wake did love pitching at the Metrodome and the Trop. His best away park was Comerica, probably due to the huge OF. Of course, Skydome was a nightmare for him (worst WHIP for any stadium he pitched at more than 5 times).
He also did well at Kauffman, most likely due to the large OF there as well.