Good analysis.
I suppose the typical manager would say 'Hell, yeah, I'd love to use my closer for 4, 5 and 6 out saves all the time but I'm afraid I'd burn him to a crisp.'
One other piece of data that might be interesting is something like Papelbon's OPS against for Pitches 1-10, 11-20 and 21-25 etc., to see the effects of fatigue.