A good place to stay is Marriott Courtyard in Brookline. It's away from downtown (and the higher prices), but there is a T stop right in front of the place and it's about 4 or 5 stops to Kenmore. Bring a credit card for when you walk in the Twins souvenir store on Yawkey Way. Take a Fenway tour one morning, I think they start at 9 and tickets are sold in the souvenir store, it's worth it. Take a Duck Boat tour to see the city, they leave from the Prudential Center. Get a win.