I like the lineup, but I'd pass on Aramis Ramirez, because I don't think the additional offense that he produces makes up for the D we would lose with Lowell. I'd prefer to keep Loretta in the 2 hole with Pedroia getting action at 2nd, 3rd and SS.
In the pitching rotation, I'd prefer to let Wakefield and Tavarez fight it out for the 5th slot while acquiring a top stud through trade or FA to take the first or second slot. I don't think Lester can be counted on for much next season. Has any major sports figure recovered from this specific cancer sufficiently enough to return as a productive professional athletic career?