I doubt the Sox will clean house right now, but they will probably be sellers at the trade deadline on July 31. Even if it means eating some money/a lot of money, they will be better off getting rid of many of Epstein's mistakes. The big question mark will be if Beckett, Youkilis, Saltamalacchia, Gonzalez, and/or Lester will be producing well enough to bring back any return.
This is sad, and I am so glad Theo is gone.