Was going to originally respond in the thread but felt this topic deserved its own.
Youk's (impending) departure is pretty noteworthy in the sense that he was really the first homegrown player the Red Sox had produced since Nixon and Nomar. From there the Red Sox were able to reel off numerous all-stars Papelbon, Lester, Pedroia, Buchholz, Ellsbury.
However since Buchholz's debut in 07 the Sox haven't had nearly that kind of success bringing up players that stuck on the roster and had a large impact, and notably the team just has not had any deep runs in the postseason since. That spans 08-11 where say Bard was the only real meaningful guy that has stuck. This is also the period where they loaded up on expensive FAs as a result of not having that kind of pipeline.
Now I really think the Sox are on the verge of the next era of home-grown raised dominance. They have a guy in Cherrington who didn't get googly eyed at some of the marquee FAs this year, hired a manager who is not a veterans-first manager (WMB over Youk), and produced the deepest bullpen the Sox have had in forever (despite losing the two best pieces) and for once we won't have to overpay for a mediocre MR.
Look at the prospects coming up the line right now WMB is here, Kalish is ready to be the RF, Doubront looks like a very consistent AL East #3, then in AAA you have Lavarnway who could very well step into the DH spot next year, Iglesias who could be the SS, Bradley in AA who could soon replace Ellsbury, Barnes cruising through the minors, and Bogearts with the highest potential of any prospect since Buchholz/Hanley.
The best part is that all of those guys are within possibly a year away from being on the MLB roster (with the exception of maybe Bogaerts). Considering the core of the old-new era of Gonzalez, Lester, Buchholz, Crawford, Pedroia, Salty, Nava? all have a minimum of 4-5 PRIME years left of their careers, I'd say this is the start of another decade of high quality Red Sox baseball.
Finally this all depends on them sticking to what has worked in the past and not tying themselves up to big name FAs and not letting go of prospects for rentals.