Cora started the season with Campbell at 2b and Casas at 1b. Both had WAR's of -0.9. Campbell lasted 67 games and Casas 29. Since Casas, Sogard, Gonzalez, and Toro have played 1b with better WAR's than Casas. Since Campbell, Gonzalez, Hamilton, Mayer, Rafaela, and maybe Toro have played 2b with better WAR's than Campbell.
With Mayer at 2b and Gonzalez at 1b, I think the Sox would be fine even though Mayer had not yet figured out how to hit lefties.
On the other hand, Bregman and Story have both been terrific at 3b and SS.
Season to date, these are key Sox OPS's: Bregman 3.9, Duran 3.9, Rafaela 3.8, Abreu 3.2, Story 3.1, Narvaez 2.7, Anthony 2.1, Gonzalez 1.3, Refsnyder 1.2.