The fact of the matter is that batting order makes such little difference over the course of the season that it is better for a manager to put hitters into spots where they feel comfortable hitting, and to alternate righties and lefties to avoid allowing the opposing team's LOOGY to pitch to more than one lefty, than it is to try to put the "stereotypical" #3 hitter into the #3 slot. The idea that the #3 hitter should be your best hitter is a traditionalist view which has been proven false.
The optimal lineup in terms of importance of OBP should be 1, 4, 2, 5, 3, 6, 7, 8, 9, which would make our lineup look like this: Holt, De Aza (or Victorino), Betts, Hanigan, Bogaerts, Ortiz, Ramirez, Sandoval, Napoli. This goes so much against traditional thinking that a manager would never do this.