Agree that it's Ortiz with Dice-K a close second.
Although... if you had told me during his HR drought last year that he would finish with 28 HR and 99 RBI, I would not have believed it for a second. Lets just assume this year he doesn't go 35-40 games or whatever it was before he hit his first homer. If he's a little more consistent I think he could still hit somewhere around 30-35 home runs this year. That would not shock me much.
The OBP however, has fallen off a cliff the past 2 years. Lets hope he can right the ship there and at least bump it up a little bit from '09.