I believe in the righty-lefty thing--that it favors the hitter--but not devoutly. In the end so much depends on execution by the starter. If he has a good changeup, that's a leveler. Good fastball well placed is too. And, if he is a lefty against righties, even a sharp breaking curve or slider can work.
As for Eovaldi vs. Houston, he did get tagged for 4 solo dingers on June 20. Awful. But he faced the Yankees 3 times for 16 innings in Aug-Sep without giving up any dingers. He pitched 20 innings in September without any dingers. So there is hope.
If there is a theme to the Sox pitching in this postseason, it just might be, keep the ball in the park. Worked great in Yankee Stadium and was maybe why the Sox gave up 15 walks in the first two ALCS games. Sale and Price together gave up 8--4 apiece.