The Sox had a good number of very loud outs against Masterson, so the "looked like a team playing for the rain to end the game" bit doesn't stick, IMO. They had good at-bats, but you can't beat luck, and the Guardians have been the luckiest team in baseball to date. Don't take this the wrong way, but baseball is a funny game. Sometimes the liners are right at people, sometimes pitcher's pitches get hit, etc. You have to have a lot of that on your side to have such a strong record in 1-run games.
I hang this loss on Francona. It made no sense to pull Buchholz, however, assuming that 90+ pitches was his limit due to the 127 in the start before, the pitcher to relieve him was Hill. It turns Santana around to his weaker side, but more importantly faces Brantley with a strong platoon advantage. He f***ed up again. No surprise there.