Bunch of ?'s.
As far as upsets go, I like Old Dominion, Davidson, Georgia Tech, and Winthrop. The Midwest is easily the weakest out of the four, and should have some excellent first day matchups. I don't think Wisconsin will advance past Georgia Tech. They don't have that dominant big man presence, and aren't athletic enough to compensate for it. Florida should easily advance to the Final Four. This year's George Mason, will be Winthrop. I would put down Old Dominion, but they aren't going to beat Florida.
In the West, I like VCU to go to the Sweet 16. Duke should be lower than a six, and Pittsburgh always seems to lose when they should win. I'm having the toughest time picking this one. VT/Illinois? Probably a 50-47 shootout. Kentucky/'Nova? Indiana/Gonzaga? D.J White shows up, they could threaten UCLA.
Other than Ohio State, and Texas A&M, is there anyone in the South who scares you? Memphis hasn't played anyone, and could be dispatched by Creighton. How good is Nevada? Can Texas A&M beat Ohio State?
We can only hope for a Kevin Durant v North Carolina matchup. Does anyone know a thing about Washington St.? They could get bumped by Oral Roberts. Green, Tufts, and King are a pretty lethal trio for the Eagles. Georgetown looks like they have the bullets to win three games, they'll probably get knocked out with their zero guard approach.
I guess I would have to say:
Florida
UCLA
UNC
Texas A&M
is my Final Four. I have Winthrop, Kansas, Washington St.?, and Ohio St. in the elite 8. I have very little confidence in these picks. I will probably spend the next 48 hours examining every possible angle.
(BTW, find as many Catholics as you can, and get them to join your pool. Chances are, they will pick Norte Dame, or B.C)