That HBP was actually the fourth ball to Rizzo, so it wasn't "one pitch."
Roble's first pitch was wild and cost a run, so you might have a point there. However, Robles is a high heat reliever. He loves fastballs and throws a lot of them. So why oh why throw a slider on his first pitch with a man on 3b?
And, I'm sorry, but three different relievers stunk in a close game against the Yankees in a late September game that makes a real difference. So did Eovaldi Friday. I don't think this was just random fate intruding. The Yankees pitchers, meanwhile, seemed to know what they were doing and pretty much dominated the Sox hitters despite the August addition of Schwarber, the September addition of Iglesias, the return of Kike, the vastly improved hitting of Dalbec, etc.