Our typical line up of Ells - Pedey - Gonzo - Youk - McDonald - Scutaro - Cam - Salty - Pitcher has a career .345 average against Cliff Lee. Included in that is Adrian Gonzalez, who has absolutely owned Lee (7 for 10 against him).
Against Oswalt, we've only got 3 guys on our roster that have faced him (Drew, Cam, and Gonzo), and they are a combined 20 for 65 against him (.308).
Worley is a rookie, so we don't have anyone who has faced him.
Regardless, I'll pair up Beckett vs Lee all day. Lackey vs Oswalt, they have an edge, although I could see our offense busting that game open. And Lester vs Worley, that's Lester all day unless we have that mysterious spell cast on our offense by rookies again.