East:
The most loaded region, IMO. Tennessee has a bit of a rough draw, but then again, no games are easy other than the 1/16 games.
Favorite: It has to be North Carolina. The most talented team in the region, hasn't lost a game away from Chapel Hill all year, and they have the player of the year candidate. The question is whether or not they can get enough key stops to win. It's unlikely a team gives up 70+ and wins many games (like the Heels did to Clemson and Va Tech over the weekend), but they have offensive firepower to burn.
Dark Horse: Winthrop. I've really enjoyed this team's run the last few years. They are a very dangerous tournament team. In my opinion, Washington State is a very weak 4 and that is a very winnable game for Winthrop. If Winthrop wins and Notre Dame takes care of business against George Mason, it would be a rematch of a first round game last year (which Winthrop won).
Overrated Team: Washington State. Very unimpressed with them all year. If you keep Derrick Low in check you can have success against them.
Winner: I'll take North Carolina for all the reasons I mentioned above.