I like several of elsrbueno's ideas, particularly the idea of keeping Bill M. and starting Youk at first. Youk's an upgrade over who is currently at 1B, and the Sox already have the best offense in MLB.
Pitching is the key. I say pursue Burnett, but if you can't get him it's okay because everyone has left someone off their rotation and bullpen assignments for next year. I think the missing name, Papelbon, should and will make the starting rotation next year.
Wagner is a premium closer and is unlikely to go anywhere that wants to demote him to setup guy. Ryan's not quite in the same category as Wagner, but I would expect the same situation with him.