My defense vs. B22407's offense:
I think this is a very good matchup for my defense. My entire defensive scheme is predicated on getting to the QB, and that's exactly what I would be trying to do in this game. Ware and Harrison rushing Vick off the edge should do a very good job of keeping him in the pocket, along with Antrel Rolle and Roman Harper playing up in the box from time to time, and also applying pressure by blitzing the C gaps. Because of B22407's relatively weak receiving corp, I should be able to load up the box, and prevent big plays in the running game. All my linebackers are very disciplined against the run (except for Ware at times), and will do a good job of staying in their lanes and keeping containment against Vick and Johnson. I'll show some cover two from time to time, but I trust Hall and Joseph (and Phillips playing centerfield on passing downs) to handle pass defense when Vick is able to get the ball away cleanly.
My offense vs. B22407's defense:
B22407 made the mistake of drafting 4-3 pass rushing DEs (Umenyiora and Williams), and playing them in a 3-4. Osi would be completely ineffective in this defense, and it would hurt Williams as well. That will severely hurt his ability to rush the passer, and should help my pass heavy offense. My primary offensive set would be 3 WRs (Holmes, Nicks, and Royal), 1 TE (Cooley), and 1 RB (Bradshaw or Bush), and with Rodgers having time to stand in the pocket and allow the play to develop, I expect lots of success in the passing game (also remember that Reed may not even be in the NFL in 3 years). I also think I could have some success playing bigger sets on offense, because B22407's defensive line is almost a guarantee to struggle against the run.
Special Teams:
Neither of us have a significant advantage in this department, and it should hardly be game changing.