XB was not alone in game 2 but he was farther off the page with Wacha than most of the more experienced Sox hitters. All of them should have been sitting more on that change considering how Wacha uses it and considering that it is not a secret how he uses it.
Generally speaking if the location is good on the change and it is a good change (thrown with same arm angle as FB with major dif in velo) then even expecting it, it can be a tough pitch to hit. However Wacha left some in horrid locations for the Change both to XB and other Sox batters as well. If the Change is left in a bad location it can be a very easy pitch to hit even if you are looking FB. You have to get the bat on the same plane with it and keep the head of the bat in the hitting zone as long as possible. If it is in a bad location and you are looking for it, it should end up resting in some parking lot across the street from the outfield fences. I do think XB's inexperience at the plate at the ML level showed a bit in game 2. Still, you absolutely have to be careful where you would use WMB and today is not the day IMO.