My D against his offense
While Phil Rivers to his receivers and Vernon Davis is a solid threat, I have an elite pass rush with Cole, Mathews, and Orapko coming off the edge, and DRC and Porter should be able to limit passes effectively. In addition, I have two elite safeties in Atogwe and Branch to limit the passing game as well. His running backs are solid as well, but my linebackers are all stacked, from outside to the middle, and they should effectively limit the run, Posluszny is having a monster year so far. Also, his O-Line really isn't too good, so his pass protection and blocking will be a problem for him.
My offense vs his D
I have one of the best O-lines in the league, and he has no formidable D ends or outside linebackers to really challenge that, Kyle Orton is going to have light years to throw in the pocket, and Brandon Lloyd, Sidney Rice, and Malcom Floyd are all fast targets that put up a lot of YPR, and Orton is developing into one of the better quarterbacks in the league. My receivers will also have great chemistry with him, as Lloyd and Jaffney are his #1 and #2 receivers. I also have the best running combo in the league with AD and Arian Foster, and I don't think his line and linebackers can handle it, Fletcher is the only formidable force there. As far as his coverage, Finnegan will probably try to get into a fight every game and might be able to cover Rice effectively, but Brown will be hopeless on Lloyd. I also probably have the best FB in the league and Vince Young is a great scrambler, making my rushing essentially unstoppable against his D
Special Teams
Carpenter has arguably been the best kicker in the league this season, but kickers often don't transition from year to year. This matchup is basically a wash