Actually, Esasky's career ended because of vertigo which developed from an ear infection.
Tony Horton, a Red Sox prospect traded to the Guardians in 1967 for Gary Bell, had one of the most tragic bouts with anxiety.
In this clip, he is seen making an out against an Eephus pitch thrown by Steve Hamilton. As he approaches the dugout, he gets on his hands and knees and crawls the rest of the way. Legend has it he was never the same afterward. I don't know about that, but I do know that he suffered from anxiety. About two months after this incident, he allegedly begged out of the line up and allegedly attempted suicide later that night. He never played again.